JOURNAL ARTICLES

2008

Dodds MG, Frederiksen KS, Skak K, Hansen LT, Lundsgaard D, Thompson JA, Hughes SD.   Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins. Cancer Immunol Immunother, 2008 Oct. 17 [Epub ahead of print]

Novak AJ, Grote DM, Ziesmer SC, Rajkumar V, Doyle SE, Ansell SM.  A role for IFN-lambda1 in multiple myeloma B cell growth. Leukemia 2008 Oct. 2 [Epub ahead of print]

Mordstein M, Kochs G, Dumoutier L, Renauld JC, Paludan SR, Klucher K, Staeheli P.  Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog 2008;4(9):e1000151

Carbonatto M, Yu P, Bertolino M, Vigna E, Steidler S, Fava L, Daghero C, Roattino B, Onidi M, Ardizzone M, Peano S, Visich J, Janszen D, Dillon SR, Ponce RA.  Nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept. Toxicol Sci, 2008;105(1):200-10

Iuchi T, Teitz-Tennenbaum S, Huang J, Redman BG, Hughes SD, Li M, Jiang G, Chang AE, Li Q.  Interleukin-21 augments the efficacy of T-cell therapy by eliciting concurrent cellular and humoral responses. Cancer Res 2008;68(11):4431-41

Weaver FA, Lew W, Granke K, Yonehiro L, Delange B, Alexander WA, and Study Investigators.  A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures. J Vasc Surg 2008;47(6):1266-73

Kennedy J, Yi EC.  Use of gas-phase fractionation to increase protein identifications: application to the peroxisome. Methods Mol Biol 2008;432:217-28

Gowda A, Roda J, Hussain S-RA, Ramanuuni A, Joshi T, Schmidt S, Zhang X, Lehman A, Jarjoura D, Carson WE, Kindsvogel W, Cheney C, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC.  IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. Blood 2008;111(9):4723-30

Koren E, Smith HW, Shores E, Shankar G, Finco-Kent D, Rup B, Barrett Y-C, Devanarayan V, Gorovits B, Gupta S, Parish T, Quarmby V, Moxness M, Swanson SJ, Taniguchi G, Zuckerman LA, Stebbins CC, Mire-Sluis A.  Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products. J Immunol Methods 2008;333(1-2):1-9

Smyth MJ, Teng MW, Sharkey J, Westwood JA, Haynes NM, Yagita H, Takeda K, Sivakumar PV, Kershaw MH.  Interleukin 21 enhances antibody-mediated tumor rejection. Cancer Res 2008;68(8):3019-25

Ponce R.  Adverse consequences of immunostimulation. J Immunotoxicol 2008;5(1):33-41

Thompson JA, Curti BD, Redman BG, Bhatia S, Weber JS, Agarwala SS, Sievers EL, Hughes SD, DeVries TA, Hausman DF.  Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma. J Clin Oncol 2008;26(12):2034-39

Benson MJ, Dillon SR, Castigli E, Geha RS, Xu S, Lam K-P, Noelle RJ.  Cutting edge: The dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol 2008;180(6):3655-9

Nestorov I, Munafo A, Papasouliotis O, Visich J.  Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritis. J Clin Pharmacol 2008;48(4):406-17

Frederiksen KS, Lundsgaard D, Freeman JA, Hughes SD, Holm TL, Skrumsager BK, Petri A, Hansen LT, McArthur GA, Davis ID, Skak K.  IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma. Cancer Immunol Immunother 2008; 57(10):1439-49

Ansell SM, Witzig TE, Inwards DJ, Porrata LF, Ythier A, Ferrande L, Nestorov I, DeVries T, Dillon SR, Hausman D, Novak AJ.  Phase I clinical study of atacicept in patients with relapsed and refractory B-cell non-Hodgkin's lymphoma. Clin Cancer Res 2008;14(4):1105-10

Yaccoby S, Pennisi A, Li X, Dillon SR, Zhan F, Barlogie B, Shaughnessy JD Jr.  Atacicept (TACI-Ig) inhibits growth of TACI(high) primary myeloma cells in SCID-hu mice and in coculture with osteoclasts. Leukemia 2008;22(2):406-13

Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB, Dagnaes-Hansen F, Thomsen AR, Chen Z, Haugen H, Klucher K, Paludan SR.  An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 2008;180(4):2474-85

Tak PP, Thurlings RM, Rossier C, Nestorov I, Dimic A, Mircetic V, Rischmueller M, Nasonov E, Shmidt E, Emery P, Munafo A.  Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arthritis Rheum 2008;58(1):61-72

Clarke J, Hurst C, Martin P, Vahle J, Ponce R, Mounho B, Heidel S, Andrews L, Reynolds T, Cavagnaro J.  Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: Is 6 months still appropriate? Regul Toxicol Pharmacol 2008;50(1):2-22

Ellsworth JL, Maurer M, Harder B, Hamacher N, Lantry M, Lewis KB, Rene S, Byrnes-Blake K, Underwood S, Waggie KS, Visich J, Lewis KE.  Targeting immune complex-mediated hypersensitivity with recombinant soluble human Fc{gamma}RIA (CD64A). J Immunol 2008;180(1):580-9

2007

Dall'Era M, Chakravarty E, Wallace D, Genovese M, Weisman M, Kavanaugh A, Kalunian K, Dhar P, Vincent E, Pena-Rossi C, Wofsy D; Merck Serono and ZymoGenetics Atacicept Study Group.  Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum, 2007, 56(12): 4142-50

Davis ID, Skak K, Smyth MJ, Kristjansen PE, Miller DM, Sivakumar PV.  Interleukin-21 signaling: functions in cancer and autoimmunity. Clin Cancer Res, 2007, 13(23): 6926-32

Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD.  Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol, 2007, 179(8): 5462-73

Erickson JG, Smith AV.  A biopharmaceutical breakthrough.  Occup Health Saf 2007;76(6):141-5

Chapman WC, Singla N, Genyk Y, McNeil JW, Renkens KL Jr, Reynolds TC, Murphy A, Weaver FA.  A phase 3, randomized, double-blind comparative study of the efficacy and safety of topical recombinant human thrombin and bovine thrombin in surgical hemostasis. J Am Coll Surg 2007, 205(2): 256-65

Gribble E, Sivakumar P, Ponce R, Hughes S.  Toxicity as a result of immunostimulation by biologics. Expert Opin Drug Metab Toxicol, 2007, 3(2): 209-34

Nestorov I.  Whole-body physiologically based pharmacokinetic models. Expert Opin Drug Metab Toxicol, 2007, 3(2): 235-49

Munafo A, Priestley A, Nestorov I, Visich J, Rogge M.  Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers. Eur J Clin Pharmacol, 2007, 63(7): 647-56

Heffernan JK, Ponce RA, Zuckerman LA, Volpone JP, Visich J, Giste EE, Jenkins N, Boster D, Pederson S, Knitter G, Palmer T, Wills M, Early RJ, Rogge MC.  Preclinical safety of recombinant human thrombin. Regul Toxicol Pharmacol, 2007, 47(1): 48-58

2006

Doyle SE, Schreckhise H, Khuu-Duong K, Henderson K, Rosler R, Storey H, Yao L, Liu H, Barahmand-Pour F, Sivakumar P, Chan C, Birks C, Foster D, Clegg CH, Wietzke-Braun P, Mihm S, Klucher KM.  Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology, 2006, 44(4): 896-906

Chapman WC, Lockstadt H, Singla N, Kafie FE, Lawson JH.  Phase 2, randomized, double-blind, placebo-controlled, multicenter clinical evaluation of recombinant human thrombin in multiple surgical indications. J Thromb Haemost, 2006, 4(9): 2083-5

Chiu A, Xu W, He B, Dillon SR, Gross JA, Sievers E, Qiao X, Santini P, Hyjek E, Lee J, Cesarman E, Chadburn A, Knowles DM, Cerutti A.  Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood, 2007, 109(2): 729-39

Visich JE, Byrnes-Blake KA, Lewis KB, Meengs B, Rogge MC.  Bioavailability and relative tissue distribution of [125I]-recombinant human thrombin. J Thromb Haemost, 2006, 4(9): 1962-8

Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK.  Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation. Immunology, 2006, 119(2): 203-11

He H, Wisner P, Yang G, Hu H, Haley D, Miller W, O'Hara A, Alvord WG, Clegg CH, Fox BA, Urba WJ, Walker EB.  Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model. J Transl Med, 2006, 4: 24 

Krejsa C, Rogge M, Sadee W.  Protein therapeutics: new applications for pharmacogenetics. Nat Rev Drug Discov, 2006, 5(6): 507-21

Roque R, Ponce R, Burleson F, Cabrit M, Broly H, Rogge M.  Influenza virus host response of C57Bl/6 mice treated with TACI-Ig. Immunopharmacol Immunotoxicol, 2006, 28(1): 13-32

Smyth MJ, Hayakawa Y, Cretney E, Zerafa N, Sivakumar P, Yagita H, Takeda K.  IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy. J Immunol, 2006, 176(10): 6347-55

Fuld S, Cunningham C, Klucher K, Davison AJ, Blackbourn DJ.  Inhibition of interferon signaling by the Kaposi's sarcoma-associated herpesvirus full-length viral interferon regulatory factor 2 protein. J Virol, 2006, 80(6): 3092-7

Dillon SR, Gross JA, Ansell SM, Novak AJ.  An APRIL to remember: novel TNF ligands as therapeutic targets. Nat Rev Drug Discov, 2006, 5(3): 235-46

Bilsborough J, Leung DYM, Maurer M, Howell M, Boguniewicz M, Yao L, Storey H, LeCiel C, Harder B, Gross JA.  IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol, 2006, 117(2): 418-25

Okada S, Ellsworth J, Durnam D, Haugen H, Holloway J, Kelley M, Lewis K, Hongping R, Sheppard P, Storey H, Waggie K, Wolf A, Yao L, Webster P.  A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor. Mol Endocrinol, 2006, 20(2): 414-25.

Novak AJ, Grote DM, Ziesmer SC, Kline MP, Manske MK, Slager S, Witzig TE, Shanafelt T, Call TG, Kay NE, Jelinek D, Cerhan JR, Gross JA, Harder B, Dillon SR, Ansell SM.  Elevated serum B-lymphocyte stimulator levels in patients with familial lymphoproliferative disorders. J Clin Oncol, 2006, 24(6): 983-7

Lasser G, Guchhait P, Ellsworth J, Sheppard P, Lewis K, Bishop P, Cruz M, Lopez J, Fruebis J.  C1q-TNF related protein-1 (CTRP-1), a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking vWF binding to collagen. Blood, 2006, 107(2): 423-30

2005

Chand HS, Foster DC, Kisiel W.  Structure, function and biology of tissue factor pathway inhibitor-2. Thromb Haemost, 2005, 94(6): 1122-30

Elsawa S, Novak A, Grote D, Ziesmer S, Witzig T, Kyle R, Dillon S, Harder B, Gross J, Ansell S.  B-Lymphocyte Stimulator (BLyS) Stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom's Macroglobulinemia. Blood, 2006, 107(7): 2882-8

Weinstein JR, Hong SY, Kulman JD, Bishop C, Kuniyoshi J, Andersen H, Ransom BR, Hanisch UK, Möller T. Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations. J Neurochem, 2005, 95(4): 1177-87

Takaki R, Hayakawa Y, Nelson A, Sivakumar PV, Hughes S, Smyth M, Lanier L.  IL-21 enhances tumor rejection through a NKG2D-dependent mechanism. J Immunol, 2005, 175(4): 2167-73

Österlund P, Veckman V, Sirén J, Klucher KM, Hiscott J, Matikainen S, and Julkunen I.  Gene expression and antiviral activity of alpha/beta interferons and Interleukin-29 in virus-infected human myeloid dendritic cells.  J Virol, 2005, 79(15): 9608-17

Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, Ellsworth JL.  Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage, 2005, 13(7): 623-31

Conklin D, Haldeman B, Gao Z.  Gene finding for the helical cytokines. Bioinformatics, 2005, 21(9): 1776-81

2004

Conklin D.  Recognition of the helical cytokine fold. J Comput Biol, 2004, 11(6): 1189-1200

Bishop P, Lawson J.  Recombinant biologics for treatment of bleeding disorders. Nat Rev Drug Discov, 2004, 3(8): 684-694

Makogonenko, E, Goldstein AL, Bishop PD, Medved L.  Factor XIIIa incorporates thymosin beta4 preferentially into the fibrin(ogen) alphaC-domains. Biochemistry, 2004, 43(33): 10748-56

Novak AJ, Grote DM, Stenson M, Ziesmer SC, Witzig TE, Habermann TM, Harder B, Ristow KM, Bram RJ, Jelinek DF, Gross JA, Ansell SM.  Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome. Blood, 2004, 104(8): 2247-53

Moroz A, Eppolito C, Li Q, Tao J, Clegg CH, Shrikant PA.  IL-21 enhances and sustains CD8(+) T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15 and IL-21. J Immunol, 2004, 173(2): 900-9

Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA.  Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol, 2004, 5(7): 752-60

Mire-Sluis AR, Barrett YC, Devanarayan V, Koren E, Liu H, Maia M, Parish T, Scott G, Shankar G, Shores E, Swanson SJ, Taniguchi G, Wierda D, Zuckerman LA.  Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products. J Immunol Methods, 2004, 289(1-2): 1-16

Sivakumar PV, Foster DC, Clegg CH.  Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. Immunology, 2004, 112(2): 177-82

Krivan W.  Searching for transcription factor binding site clusters: how true are true positives? J Bioinform Comput Biol, 2004, 2(2): 413-6

Xu W.  Interleukin-20. Int Immunopharmacol, 2004, 4(5): 627-33

Pène J, Gauchat JF, Lécart S, Drouet E, Guglielmi P, Boulay V, Delwail A, Foster D, Lecron JC, Yssel H. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol, 2004, 172(9): 5154-7

Hudkins, KL, Gilbertson, DG, Carling, M, Taneda, S, Hughes, SD, Holdren, MS, Palmer, TE, Topouzis, S, Haran, AC, Feldhaus, AL, Alpers, CE.  Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy. J Am Soc Nephrol, 2004, 15(2): 286-98

Foster D, Parrish-Novak J, Fox B, Xu W.   Cytokine-receptor pairing: accelerating discovery of cytokine function. Nat Rev Drug Discov, 2004, 3(2): 160-70

Ellsworth JL, Garcia R, Yu J, Kindy MS.  Time window of fibroblast growth factor-18-mediated neuroprotection after occlusion of the middle cerebral artery in rats. J Cereb Blood Flow Metab, 2004, 24(1): 114-23

2003

Chand HS, Du X, Ma D, Inzunza HD, Kamei S, Foster D, Brodie S, Kisiel W.  The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic mice. Blood, 2004, 103(3): 1069-77

Taneda S, Hudkins KL, Topouzis S, Gilbertson DG, Ophascharoensuk V, Truong L, Johnson RJ, Alpers CE.  Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J Am Soc Nephrol, 2003, 14(10): 2544-55

Novak AJ, Darce JR, Arendt BK, Harder B, Henderson K, Kindsvogel W, Gross JA, Greipp PR, Jelinek DF.  Expression of BCMA, TACI and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood, 2004, 103(2): 689-94

Toomey JA, Gays F, Foster D, Brooks CG.  Cytokine requirements for the growth and development of mouse NK cells in vitro. J Leukoc Biol, 2003, 74(2): 233-42

Brandt K, Bulfone-Paus S, Foster DC, Rückert R.  Interleukin-21 inhibits dendritic cell activation and maturation. Blood, 2003, 102(12): 4090-8

Konduri SD, Yanamandra N, Dinh DH, Olivero WC, Gujrati M, Foster DC, Kisiel W, Rao JS.  Physiological and chemical inducers of tissue factor pathway inhibitor-2 in human glioma cells. Int J Oncol, 2003, 22(6): 1277-83

Strengell M, Matikainen S, Siren J, Lehtonen A, Foster D, Julkunen I, Sareneva T.  IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J Immunol, 2003, 170(11): 5464-9

Ellsworth JL, Garcia R, Yu J, Kindy MS.  Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats. Stroke, 2003, 34(6): 1507-12

Wasserman WW, Krivan W.  In silico identification of metazoan transcriptional regulatory regions. Naturwissenschaften, 2003, 90(4): 156-66

Mayson BE, Kilburn DG, Zamost BL, Raymond CK, Lesnicki GJ.  Effects of methanol concentration on expression levels of recombinant protein in fed-batch cultures of Pichia methanolica. Biotechnol Bioeng, 2003, 81(3): 291-8

Morgan K, Conklin D, Pawson AJ, Sellar R, Ott TR, Millar RP.  A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology, 2003, 144(2): 423-36

Zhang JL, Foster D, Sebald W.  Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain. Biochem Biophys Res Commun, 2003, 300(2): 291-6

Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM.  IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol, 2003, 4(1): 63-8

2002

Suto A, Nakajima H, Hirose K, Suzuki K, Kagami SI, Seto Y, Hoshimoto A, Saito Y, Foster DC, Iwamoto I.  Interleukin-21 prevents antigen-induced IgE production by inhibiting germline C{epsilon} transcription of IL-4-stimulated B cells. Blood, 2002, 100(13): 4565-73

Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, Brandt C, Jelinek L, Madden K, McKernan PA, Foster DC, Jaspers S, Chandrasekher YA.   IL-19, IL-20, and IL-24 signal through two distinct receptor complexes: Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem, 2002, 277(49): 475-23

Changsirikulchai S, Hudkins KL, Goodpaster TA, Volpone J, Topouzis S, Gilbertson DG, Alpers CE.  Platelet-derived growth factor-D expression in developing and mature human kidneys. Kidney Int, 2002, 62(6): 2043-54

Parrish-Novak J, Foster DC, Holly RD, Clegg CH.   Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol, 2002, 72(5): 856-63

Gorenflo VM, Smith L, Dedinsky B, Persson B, Piret JM.  Scale-up and optimization of an acoustic filter for 200 L/day perfusion of a CHO cell culture. Biotechnol Bioeng, 2002, 80(4): 438-44

Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S.  IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol, 2002, 169(7): 3600-5

Ensinck JW, Baskin DG, Vahl TP, Vogel RE, Laschansky EC, Francis BH, Hoffman RC, Krakover JD, Stamm MR, Low MJ, Rubinstein M, Otero-Corchon V, D'Alessio D.  Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation. Endocrinology, 2002, 143(7): 2599-609

Eberl M, Altincicek B, Kollas AK, Sanderbrand S, Bahr U, Reichenberg A, Beck E, Foster D, Wiesner J, Hintz M, Jomaa H.  Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology, 2002, 106(2): 200-11

Sabath DF, Lofton-Day C, Lin N, Lok S, Kaushansky K, Broudy VC.   Identification and characterization of an isoform of murine Mpl(1). Biochim Biophys Acta, 2002, 1574(3): 383-6

Ellsworth JL, Berry J, Bukowski T, Claus J, Feldhaus A, Holderman S, Holdren MS, Lum KD, Moore EE, Raymond F, Ren H, Shea P, Sprecher C, Storey H, Thompson DL, Waggie K, Yao L, Fernandes RJ, Eyre DR, Hughes SD.   Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors. Osteoarthritis Cartilage, 2002, 10(4): 308-20

Jones PBC. Digital discovery: Emerging issues for biotechnology and life sciences companies. J. Biolaw Bus, 2002, 5(1): 24-33.

Bannerman DD, Tupper JC, Kelly JD, Winn RK, Harlan JM.  The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta. J Clin Invest, 2002, 109(3): 419-25

Jonassen I, Eidhammer I, Conklin D, Taylor WR.  Structure motif discovery and mining the PDB. Bioinformatics, 2002, 18(2): 362-7

Moore EE, Presnell S, Garrigues U, Guilbot A, LeGuern E, Smith D, Yao L, Whitmore TE, Gilbert T, Palmer TD, Horner PJ, Kuestner RE.   Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Neuromuscul Disord, 2002, 12(2): 141-50

Maggio-Price L, Shows D, Waggie K, Burich A, Zeng WP, Escobar S, Morrissey P, Viney JL. Helicobacter bilis infection accelerates and H-hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) mice. Am J Pathol, 2002, 160(2): 739-51

Konduri SD, Osman FA, Rao CN, Srinivas H, Yanamandra N, Tasiou A, Dinh DH, Olivero WC, Gujrati M, Foster DC, Kisiel W, Kouraklis G, Rao JS.  Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. Oncogene, 2002, 21(6): 921-8

Conklin D, Jonassen I, Aasland R, Taylor WR.  Association of nucleotide patterns with gene function classes: application to human 3' untranslated sequences. Bioinformatics, 2002, 18(1): 182-9

2001

Nelsestuen GL, Stone M, Martinez MB, Harvey SB, Foster D, Kisiel W.  Elevated function of blood clotting Factor VIIa mutants that have enhanced affinity for membranes behavior in a diffusion-limited reaction. J Biol Chem, 2001, 276(43): 39825-31

Xu W, Presnell SR, Parrish-Novak J, Kindsvogel W, Jaspers S, Chen Z, Dillon SR, Gao Z, Gilbert T, Madden K, Schlutsmeyer S, Yao L, Whitmore TE, Chandrasekher Y, Grant FJ, Maurer M, Jelinek L, Storey H, Brender T, Hammond A, Topouzis S, Clegg CH, Foster DC.  A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci, 2001, 98(17): 9511-6

Gross JA, Dillon SR, Mudri S, Johnston J, Littau A, Roque R, Rixon M, Schou O, Foley KP, Haugen H, McMillen S, Waggie K, Schreckhise RW, Shoemaker K, Vu T, Moore M, Grossmann A, Clegg CH.  TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: impaired B cell maturation in mice lacking BLyS. Immunity, 2001, 15(2): 289-302

Gilbertson DG, Duff ME, West JW, Kelly JD, Sheppard PO, Hofstrand PD, Gao Z, Shoemaker K, Bukowski TR, Moore M, Feldhaus AL, Humes JM, Palmer TE, Hart CE. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem, 2001, 276(29): 27406-14

Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K.  Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol, 2001, 167(1): 1-5

Wu CH, Scampavia L, Ruzicka J, Zamost B.  Micro sequential injection: fermentation monitoring of ammonia, glycerol, glucose, and free iron using the novel lab-on-valve system. Analyst, 2001, 126(3): 291-7

Chandler WL, Patel MA, Gravelle L, Soltow LO, Lewis K, Bishop PD, Spiess BD.  Factor XIIIa and clot strength after cardiopulmonary bypass. Blood Coagul Fibrinolysis, 2001, 12(2): 101-8

Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA.  Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell, 2001, 104(1): 9-19


2000

Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Raymond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D.  Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature, 2000, 408(6808): 57-63

Conklin DC, Rixon MW, Kuestner RE, Maurer MF, Whitmore TE, Millar RP.  Cloning and gene expression of a novel human ribonucleoprotein. Biochim Biophys Acta, 2000, 1492(2-3): 465-9

Lok S, Johnston DS, Conklin D, Lofton-Day CE, Adams RL, Jelmberg AC, Whitmore TE, Schrader S, Griswold MD, Jaspers SR.  Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and rat. Biol Reprod, 2000, 62(6): 1593-9

Conklin D, Holderman S, Whitmore TE, Maurer M, Feldhaus AL.  Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain. Gene, 2000, 249(1-2): 91-8

D'Argenio G, Grossmann A, Cosenza V, DellaValle N, Mazzacca G, Bishop PD.  Recombinant Factor XIII improves established experimental colitis in rats. Dig Dis Sci, 2000, 45(5): 987-97

Ellsworth JL, Hamacher N, Bagwell N, West JW.  Detection of Glu-Glu-tagged proteins in mammalian cell culture media by dot immunoblotting. BioTechniques, 2000, 28(5): 934-7

Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A, Grossmann A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W, Clegg CH.  TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature, 2000, 404(6781): 995-9

Davies MG, Owens EL, Mason DP, Lea H, Tran PK, Vergel S, Hawkins SA, Hart CE, Clowes AW.  Effect of platelet-derived growth factor receptor-alpha and -beta blockade on flow-induced neointimal formation in endothelialized baboon vascular grafts. Circ Res, 2000, 86(7): 779-86

Shoemaker K, Holloway JL, Whitmore TE, Maurer M, Feldhaus AL.  Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T. Gene, 2000, 245(1): 103-8

Conklin D, Yee DP, Millar R, Engelbrecht J, Vissing H.  Mining of assembled expressed sequence tag (EST) data for protein families: application to the G protein-coupled receptor superfamily. Brief Bioinform, 2000, 1(1): 93-9

Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S.  Human secretin (SCT): Gene structure, chromosome location, and distribution of mRNA. Cytogenet Cell Genet, 2000, 90(1-2): 47-52

Whitmore TE, Maurer MF, Sexson S, Raymond F, Conklin D, Deisher TA.  Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization. Cytogenet Cell Genet, 2000, 90(3-4): 231-3


1999

Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, Walker KM, Chen LH, Wattler S, Nehls M, Lewis KB. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics, 1999, 62(3): 477-82

Raymond CK, Mugford VR, Sexson SL.  Plasmid topologies that enhance the transformation efficiency of yeast. BioTechniques, 1999, 27(5): 892-6

Conklin D, Lofton-Day CE, Haldeman BA, Ching A, Whitmore TE, Lok S, Jaspers S.  Identification of INSL5, a new member of the insulin superfamily. Genomics, 1999, 60(1): 50-6

Moore EE, Kuestner RE, Conklin DC, Whitmore TE, Downey W, Buddle MM, Adams RL, Bell LA, Thompson DL, Wolf A, Chen L, Stamm MR, Grant FJ, Lok S, Ren H, De Jongh KS.  Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. Horm Metab Res, 1999, 31(7): 406-14

Fox BA, Yee VC, Pedersen LC, LeTrong I, Bishop PD, Stenkamp RE, Teller DC.   Identification of the calcium binding site and a novel ytterbium site in blood coagulation Factor XIII by X-ray crystallography. J Biol Chem, 1999, 274(8): 4917-23

Hart CE, Kraiss LW, Vergel S, Gilbertson D, Kenagy R, Kirkman T, Crandall D L, Tickle S, Finney H, Yarranton G, Clowes AW.  PDGFbeta receptor blockade inhibits intimal hyperplasia in the baboon. Circulation, 1999, 99(4): 564-9

Raymond CK, Pownder TA, Sexson SL.  General method for plasmid construction using homologous recombination. BioTechniques, 1999, 26(1): 134-41

Whitmore TE, Maurer MF, Day HL, Jelmberg AC, Dasovich MM, Sundborg LM, Burkhead SK, Heipel MD, Madden KL, Kramer JM, Kuijper JL, Xu WF, Jaspers SR, Holly RD, Lok S.  The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21-->q23 by the use of radiation hybrid mapping. Cytogenet Cell Genet, 1999, 87(1-2): 93-4