JOURNAL ARTICLES
2008
Weaver FA, Lew W, Granke K, Yonehiro L, Delange B, Alexander WA, and Study Investigators. A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures. J Vasc Surg 2008;Apr 25 [Epub ahead of print]
Kennedy J, Yi EC. Use of gas-phase fractionation to increase protein identifications: application to the peroxisome. Methods Mol Biol 2008;432:217-28
Gowda A, Roda J, Hussain S-RA, Ramanuuni A, Joshi T, Schmidt S, Zhang X, Lehman A, Jarjoura D, Carson WE, Kindsvogel W, Cheney C, Caligiuri MA, Tridandapani S, Muthusamy N, Byrd JC. IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. Blood 2008;111(9):4723-30
Koren E, Smith HW, Shores E, Shankar G, Finco-Kent D, Rup B, Barrett Y-C, Devanarayan V, Gorovits B, Gupta S, Parish T, Quarmby V, Moxness M, Swanson SJ, Taniguchi G, Zuckerman LA, Stebbins CC, Mire-Sluis A. Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products. J Immunol Methods 2008;333(1-2):1-9
Smyth MJ, Teng MW, Sharkey J, Westwood JA, Haynes NM, Yagita H, Takeda K, Sivakumar PV, Kershaw MH. Interleukin 21 enhances antibody-mediated tumor rejection. Cancer Res 2008;68(8):3019-25
Ponce R. Adverse consequences of immunostimulation. J Immunotoxicol 2008;5(1):33-41
Thompson JA, Curti BD, Redman BG, Bhatia S, Weber JS, Agarwala SS, Sievers EL, Hughes SD, DeVries TA, Hausman DF. Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma. J Clin Oncol 2008;26(12):2034-39
Benson MJ, Dillon SR, Castigli E, Geha RS, Xu S, Lam K-P, Noelle RJ. Cutting edge: The dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol 2008;180(6):3655-9
Nestorov I, Munafo A, Papasouliotis O, Visich J. Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritis. J Clin Pharmacol 2008;48(4):406-17
Frederiksen KS, Lundsgaard D, Freeman JA, Hughes SD, Holm TL, Skrumsager BK, Petri A, Hansen LT, McArthur GA, Davis ID, Skak K. IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma. Cancer Immunol Immunother
2008; Feb 20 [Epub ahead of print]
Ansell SM, Witzig TE, Inwards DJ, Porrata LF, Ythier A, Ferrande L, Nestorov I, DeVries T, Dillon SR, Hausman D, Novak AJ. Phase I clinical study of atacicept in patients with relapsed and refractory B-cell non-Hodgkin's lymphoma. Clin Cancer Res 2008;14(4):1105-10
Yaccoby S, Pennisi A, Li X, Dillon SR, Zhan F, Barlogie B, Shaughnessy JD Jr. Atacicept (TACI-Ig) inhibits growth of TACI(high) primary myeloma cells in SCID-hu mice and in coculture with osteoclasts. Leukemia 2008;22(2):406-13
Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB, Dagnaes-Hansen F, Thomsen AR, Chen Z, Haugen H, Klucher K, Paludan SR. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 2008;180(4):2474-85
Tak PP, Thurlings RM, Rossier C, Nestorov I, Dimic A, Mircetic V, Rischmueller M, Nasonov E, Shmidt E, Emery P, Munafo A. Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arthritis Rheum 2008;58(1):61-72
Clarke J, Hurst C, Martin P, Vahle J, Ponce R, Mounho B, Heidel S, Andrews L, Reynolds T, Cavagnaro J. Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: Is 6 months still appropriate? Regul Toxicol Pharmacol 2008;50(1):2-22
Ellsworth JL, Maurer M, Harder B, Hamacher N, Lantry M, Lewis KB, Rene S, Byrnes-Blake K, Underwood S, Waggie KS, Visich J, Lewis KE. Targeting immune complex-mediated hypersensitivity with recombinant soluble human Fc{gamma}RIA (CD64A). J Immunol 2008;180(1):580-9
2007
Dall'Era M, Chakravarty E, Wallace D, Genovese M, Weisman M, Kavanaugh A, Kalunian K, Dhar P, Vincent E, Pena-Rossi C, Wofsy D; Merck Serono and ZymoGenetics Atacicept Study Group. Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum, 2007, 56(12): 4142-50
Davis ID, Skak K, Smyth MJ, Kristjansen PE, Miller DM, Sivakumar PV. Interleukin-21 signaling: functions in cancer and autoimmunity. Clin Cancer Res, 2007, 13(23): 6926-32
Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol, 2007, 179(8): 5462-73
Erickson JG, Smith AV. A biopharmaceutical breakthrough. Occup Health Saf 2007;76(6):141-5
Chapman WC, Singla N, Genyk Y, McNeil JW, Renkens KL Jr, Reynolds TC, Murphy A, Weaver FA. A phase 3, randomized, double-blind comparative study of the efficacy and safety of topical recombinant human thrombin and bovine thrombin in surgical hemostasis. J Am Coll Surg 2007, 205(2): 256-65
Gribble E, Sivakumar P, Ponce R, Hughes S. Toxicity as a result of immunostimulation by biologics. Expert Opin Drug Metab Toxicol, 2007, 3(2): 209-34
Nestorov I. Whole-body physiologically based pharmacokinetic models. Expert Opin Drug Metab Toxicol, 2007, 3(2): 235-49
Munafo A, Priestley A, Nestorov I, Visich J, Rogge M. Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers. Eur J Clin Pharmacol,
2007, 63(7): 647-56
Heffernan JK, Ponce RA, Zuckerman LA, Volpone JP, Visich J, Giste EE, Jenkins N, Boster D, Pederson S, Knitter G, Palmer T, Wills M, Early RJ, Rogge MC. Preclinical safety of recombinant human thrombin. Regul Toxicol Pharmacol, 2007, 47(1): 48-58
2006
Doyle SE, Schreckhise H, Khuu-Duong K, Henderson K, Rosler R, Storey H, Yao L, Liu H, Barahmand-Pour F, Sivakumar P, Chan C, Birks C, Foster D, Clegg CH, Wietzke-Braun P, Mihm S, Klucher KM. Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology, 2006, 44(4): 896-906
Chapman WC, Lockstadt H, Singla N, Kafie FE, Lawson JH. Phase 2, randomized, double-blind, placebo-controlled, multicenter clinical evaluation of recombinant human thrombin in multiple surgical indications. J Thromb Haemost, 2006, 4(9): 2083-5
Chiu A, Xu W, He B, Dillon SR, Gross JA, Sievers E, Qiao X, Santini P, Hyjek E, Lee J, Cesarman E, Chadburn A, Knowles DM, Cerutti A. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood,
2007, 109(2): 729-39
Visich
JE, Byrnes-Blake KA, Lewis KB, Meengs
B, Rogge MC. Bioavailability and relative
tissue distribution of [125I]-recombinant
human thrombin. J Thromb Haemost,
2006, 4(9): 1962-8
Smith
EL, Finney HM, Nesbitt AM, Ramsdell F,
Robinson MK. Splice variants of human
FOXP3 are functional inhibitors of human
CD4+ T-cell activation. Immunology,
2006, 119(2): 203-11
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W, O'Hara A, Alvord WG, Clegg CH, Fox
BA, Urba WJ, Walker EB. Combined IL-21
and low-dose IL-2 therapy induces anti-tumor
immunity and long-term curative effects
in a murine melanoma tumor model. J
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Krejsa
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new applications for pharmacogenetics.
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Roque
R, Ponce R, Burleson F, Cabrit M, Broly
H, Rogge M. Influenza virus host response
of C57Bl/6 mice treated with TACI-Ig.
Immunopharmacol
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P, Yagita H, Takeda K. IL-21 enhances
tumor-specific CTL induction by anti-DR5
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Fuld
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Blackbourn DJ. Inhibition of interferon
signaling by the Kaposi's sarcoma-associated
herpesvirus full-length viral interferon
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Dillon
SR, Gross JA, Ansell SM, Novak AJ. An
APRIL to remember: novel TNF ligands as
therapeutic targets. Nat
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Bilsborough
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M, Yao L, Storey H, LeCiel C, Harder B,
Gross JA. IL-31 is associated with cutaneous
lymphocyte antigen-positive skin homing
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J Allergy Clin Immunol, 2006,
117(2): 418-25
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J, Kelley M, Lewis K, Hongping R, Sheppard
P, Storey H, Waggie K, Wolf A, Yao L,
Webster P. A glycoprotein hormone
expressed in corticotrophs exhibits unique
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Novak
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Call TG, Kay NE, Jelinek D, Cerhan JR,
Gross JA, Harder B, Dillon SR, Ansell
SM. Elevated serum B-lymphocyte stimulator
levels in patients with familial lymphoproliferative
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Clin Oncol, 2006, 24(6): 983-7
Lasser G, Guchhait P, Ellsworth J,
Sheppard P, Lewis K, Bishop P, Cruz M,
Lopez J, Fruebis J. C1q-TNF related protein-1
(CTRP-1), a vascular wall protein that
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2006, 107(2): 423-30
2005
Chand
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and biology of tissue factor pathway inhibitor-2.
Thromb Haemost, 2005, 94(6): 1122-30
Elsawa
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T, Kyle R, Dillon S, Harder B, Gross J,
Ansell S. B-Lymphocyte Stimulator (BLyS)
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malignant B-cell growth in Waldenstrom's
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2006, 107(7): 2882-8
Weinstein
JR, Hong SY, Kulman JD, Bishop C, Kuniyoshi
J, Andersen H, Ransom BR, Hanisch UK,
Möller T. Unraveling thrombin's true microglia-activating
potential: markedly disparate profiles
of pharmaceutical-grade and commercial-grade
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Neurochem, 2005, 95(4): 1177-87
Takaki R, Hayakawa Y, Nelson A, Sivakumar
PV, Hughes S, Smyth M, Lanier L. IL-21
enhances tumor rejection through a NKG2D-dependent
mechanism.
J Immunol, 2005, 175(4): 2167-73
Österlund
P, Veckman V, Sirén J, Klucher
KM, Hiscott J, Matikainen S, and Julkunen
I. Gene expression and antiviral activity
of alpha/beta interferons and Interleukin-29
in virus-infected human myeloid dendritic
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J Virol, 2005, 79(15): 9608-17
Moore EE, Bendele AM, Thompson DL,
Littau A, Waggie KS, Reardon B, Ellsworth
JL. Fibroblast growth factor-18 stimulates
chondrogenesis and cartilage repair in
a rat model of injury-induced osteoarthritis.
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Conklin D, Haldeman B, Gao Z. Gene
finding for the helical cytokines. Bioinformatics,
2005, 21(9): 1776-81
2004
Conklin D. Recognition of the helical
cytokine fold. J
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Bishop P, Lawson J. Recombinant biologics
for treatment of bleeding disorders. Nat
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Makogonenko, E, Goldstein AL, Bishop
PD, Medved L. Factor XIIIa incorporates
thymosin beta4 preferentially into the
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2004, 43(33): 10748-56
Novak AJ, Grote DM, Stenson M, Ziesmer
SC, Witzig TE, Habermann TM, Harder B,
Ristow KM, Bram RJ, Jelinek DF, Gross
JA, Ansell SM. Expression of BLyS and
its receptors in B-cell non-Hodgkin lymphoma:
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2004, 104(8): 2247-53
Moroz
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Shrikant PA. IL-21 enhances and sustains
CD8(+) T cell responses to achieve durable
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of IL-2, IL-15 and IL-21. J
Immunol, 2004, 173(2): 900-9
Dillon SR, Sprecher C, Hammond A,
Bilsborough J, Rosenfeld-Franklin M, Presnell
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J, Bort S, Mudri S, Kuijper JL, Bukowski
T, Shea P, Dong DL, Dasovich M, Grant
FJ, Lockwood L, Levin SD, LeCiel C, Waggie
K, Day H, Topouzis S, Kramer J, Kuestner
R, Chen Z, Foster D, Parrish-Novak J,
Gross JA. Interleukin 31, a cytokine produced
by activated T cells, induces dermatitis
in mice. Nat
Immunol, 2004, 5(7): 752-60
Mire-Sluis AR, Barrett YC, Devanarayan
V, Koren E, Liu H, Maia M, Parish T, Scott
G, Shankar G, Shores E, Swanson SJ, Taniguchi
G, Wierda D, Zuckerman LA. Recommendations
for the design and optimization of immunoassays
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Sivakumar
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2004, 112(2): 177-82
Krivan W. Searching for transcription
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Pène J, Gauchat JF, Lécart S, Drouet
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D, Lecron JC, Yssel H. Cutting edge: IL-21
is a switch factor for the production
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Immunol, 2004, 172(9): 5154-7
Hudkins, KL, Gilbertson, DG, Carling,
M, Taneda, S, Hughes, SD, Holdren, MS,
Palmer, TE, Topouzis, S, Haran, AC, Feldhaus,
AL, Alpers, CE. Exogenous PDGF-D is a
potent mesangial cell mitogen and causes
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Foster D, Parrish-Novak J, Fox B, Xu W.
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Ellsworth JL, Garcia R, Yu J, Kindy
MS. Time window of fibroblast growth factor-18-mediated
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2003
Chand HS, Du X, Ma D, Inzunza HD, Kamei
S, Foster D, Brodie S, Kisiel W. The effect
of human tissue factor pathway inhibitor-2
on the growth and metastasis of fibrosarcoma
tumors in athymic mice. Blood,
2004, 103(3): 1069-77
Taneda S, Hudkins KL, Topouzis S,
Gilbertson DG, Ophascharoensuk V, Truong
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Novak AJ, Darce JR, Arendt BK, Harder
B, Henderson K, Kindsvogel W, Gross JA,
Greipp PR, Jelinek DF. Expression of BCMA,
TACI and BAFF-R in multiple myeloma: a
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2004, 103(2): 689-94
Toomey JA, Gays F, Foster D, Brooks
CG. Cytokine requirements for the growth
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Brandt K, Bulfone-Paus S, Foster
DC, Rückert R. Interleukin-21 inhibits
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Blood,
2003, 102(12): 4090-8
Konduri SD, Yanamandra N, Dinh DH,
Olivero WC, Gujrati M, Foster DC, Kisiel
W, Rao JS. Physiological and chemical
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Strengell M, Matikainen S, Siren
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T. IL-21 in synergy with IL-15 or IL-18
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Zhang JL, Foster D, Sebald W. Human
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Grossmann A, Clegg CH. TACI-Ig
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